SHERRINGTON, Charles Scott (1857-1952). The Integrative Action of the Nervous System . New York: Charles Scribner's Sons, 1906. 8 o . Half-title. Line-block figures in text. Original dark green cloth. Provenance : E.A. Shafer (signature on title). FIRST EDITION of a work whose significance in the history of science and medicine has been compared with that of Harvey's De motu cordis or Newton's Principia . PRESENTATION COPY, inscribed by the author on the half-title: "With best regards C.S.S." "Sherrington was the most important neurophysiologist Britain has produced, and perhaps the most remarkable neuroscientist ever to have lived. His work bridged the gap between the theoretical and speculative neurology of the nineteenth century and the empirical science of the twentieth. He carried out an extensive program of experimentation, and the results of these investigations placed clinical neurology on a sound scientific footing ... In studying the nervous system, Sherrington began with the most primitive and simple nervous function, the reflex, which he spent years investigating and analyzing; he understood that as the atom was considered to be the most elemental particle of all material things, so the reflex was the most basic form of all nervous activity. At the heart of the reflex is the connection between nerve cells, which he was the first to call the synapse, and he hypothesized, long before it could be demonstrated, that secreted chemical mediators carried impulses from one neuron to another" (Grolier Medicine ). Garrison-Morton 1432; Heirs of Hippocrates 2198; PMM 397; Norman 1939. [ With: ] SHERRINGTON, Charles. Five titles, comprising: "Experiments in examination of the peripheral distribution of the fibers of the posterior roots of some spinal nerves," parts 1 and 2. Offprints from: Phil. Trans. Roy. Soc. Lon. , vol. 184 (1893), pp 641-763 and vol. 190 (1898), pp. 45-186. 2 parts in one, 4 o . Plates. Modern linen, printed wrappers bound in. Provenance : Solly Zuckerman (signature on front wrapper). -- Selected Writings . Ed. by D. Denny-Brown. 8 o . Original cloth. Provenance : Solly Zuckerman (signature on front free endpaper). -- Mammalian Physiology . Oxford: Clarendon Press, 1919. 4 o . Original limp cloth. Provenance : Prof. G.P. Wells, Trinity College, Cambridge (signature on pastedown). -- A bound volume containing 13 neurophysiological papers, 1889-1932. Red buckram, with original wrappers bound in. A list of the included titles is available from the department. (5)
SHERRINGTON, Charles Scott (1857-1952). The Integrative Action of the Nervous System . New York: Charles Scribner's Sons, 1906. 8 o . Half-title. Line-block figures in text. Original dark green cloth. Provenance : E.A. Shafer (signature on title). FIRST EDITION of a work whose significance in the history of science and medicine has been compared with that of Harvey's De motu cordis or Newton's Principia . PRESENTATION COPY, inscribed by the author on the half-title: "With best regards C.S.S." "Sherrington was the most important neurophysiologist Britain has produced, and perhaps the most remarkable neuroscientist ever to have lived. His work bridged the gap between the theoretical and speculative neurology of the nineteenth century and the empirical science of the twentieth. He carried out an extensive program of experimentation, and the results of these investigations placed clinical neurology on a sound scientific footing ... In studying the nervous system, Sherrington began with the most primitive and simple nervous function, the reflex, which he spent years investigating and analyzing; he understood that as the atom was considered to be the most elemental particle of all material things, so the reflex was the most basic form of all nervous activity. At the heart of the reflex is the connection between nerve cells, which he was the first to call the synapse, and he hypothesized, long before it could be demonstrated, that secreted chemical mediators carried impulses from one neuron to another" (Grolier Medicine ). Garrison-Morton 1432; Heirs of Hippocrates 2198; PMM 397; Norman 1939. [ With: ] SHERRINGTON, Charles. Five titles, comprising: "Experiments in examination of the peripheral distribution of the fibers of the posterior roots of some spinal nerves," parts 1 and 2. Offprints from: Phil. Trans. Roy. Soc. Lon. , vol. 184 (1893), pp 641-763 and vol. 190 (1898), pp. 45-186. 2 parts in one, 4 o . Plates. Modern linen, printed wrappers bound in. Provenance : Solly Zuckerman (signature on front wrapper). -- Selected Writings . Ed. by D. Denny-Brown. 8 o . Original cloth. Provenance : Solly Zuckerman (signature on front free endpaper). -- Mammalian Physiology . Oxford: Clarendon Press, 1919. 4 o . Original limp cloth. Provenance : Prof. G.P. Wells, Trinity College, Cambridge (signature on pastedown). -- A bound volume containing 13 neurophysiological papers, 1889-1932. Red buckram, with original wrappers bound in. A list of the included titles is available from the department. (5)
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